The resolution revolution in molecular imaging – new challenges and opportunities for structural biologists

Professor James Whisstock1

1Director, Australian Research Council (ARC), Centre of Excellence in Advanced Molecular Imaging


The development of a new generation of electron microscopes and direct electron detectors is permitting structural biologists to determine near-atomic resolution insights into hard-to-study macromolecular assemblies both in vitro and in situ. EM-based workflows for structure determination present major new challenges for the life science community, particularly with respect to efficient processing of large datasets. This talk will focus on current approaches for EM data analysis, together with a discussion of likely future developments in the field of biological Electron Microscopy.